Increased mesangial cGMP levels prevent mesangial cell proliferation and matrix expansion in experimental glomerulonephritis
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منابع مشابه
Stimulation of Soluble Guanylyl Cyclase (sGC) Inhibits Mesangial Cell Proliferation and Matrix Accumulation in Experimental Glomerulonephritis
Background: To date no specific treatment is established in mesangial proliferative glomerulonephritis in man. Specific stimulation of soluble guanylyl cyclase (sGC), an enzyme catalyzing the synthesis of cyclic GMP from GTP, can be achieved by the novel pyrazolopyridine derivative Bay 41-2272. In this study, we investigated the effects of sGC stimulation in experimental mesangial proliferative...
متن کاملStimulation of soluble guanylyl cyclase inhibits mesangial cell proliferation and matrix accumulation in experimental glomerulonephritis.
To date, no specific treatment is established in mesangial proliferative glomerulonephritis in humans. Specific stimulation of soluble guanylyl cyclase (sGC), an enzyme catalyzing the synthesis of cGMP from GTP, can be achieved by the novel pyrazolopyridine derivative BAY 41-2272. The effect of sGC stimulation via BAY 41-2272 on mesangial proliferation was assessed in vivo using a mesangial pro...
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Platelet-derived growth factor (PDGF), a potent mitogen for mesenchymal cells in culture, is expressed in vivo in a variety of inflammatory conditions associated with cell proliferation, including atherosclerosis, wound repair, pulmonary fibrosis, and glomerulonephritis. However, it is not known if PDGF mediates the fibroproliferative responses that characterize these inflammatory disorders. We...
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The therapeutic effects of saccharolytic and proteolytic enzymes were investigated in models of IgA nephropathy. Mesangial glomerulonephritis was induced in mice by intravenous injection of preformed soluble immune complexes of dextran sulfate and either IgA (J 558) or IgM (MOPC 104 E) antidextran MAb (passive model) or by immunization with DEAE dextran (active model). In the passive model, onl...
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ژورنال
عنوان ژورنال: BMC Pharmacology
سال: 2007
ISSN: 1471-2210
DOI: 10.1186/1471-2210-7-s1-p29